Monday, August 26, 2013

Acknowledge Your Depression


Acknowledging depression is a great start to combating the symptoms. Once a person is are aware that they have some symptoms, then they can actually do something about it and there is no reason to be ashamed.

Sometimes people delay seeking help because they think that depression is embarrassing. In the past there has been a stigma attached to having depression but that is an old fashioned belief that is no longer relevant in today's society.

It is far more important to acknowledge depression so that it is possible to begin to move forward. There may still be feelings like there is something wrong, because nothing has changed and symptoms persist, and this way of thinking is quite correct. However first class treatment is available for sufferers of depression, as much as it is for other people needing treatment for various other complaints.

A simplified description of some of the feelings associated with the symptoms of depression is:
• Feeling in a low mood
• Feeling weighted down by your circumstances
• Unwilling to try to join in with friends or family activities
• Prolonged periods of doom and gloom
• Feeling anxious or angry
• Suffering from insomnia or over sleeping

Depression symptoms generally can be described as sadness that lasts for too long. Of course it is true that most everyone gets sad at some point in their life, but depression is much more than that. It is more of a feeling that you are weighed down with a heavy load, and cannot drag yourself up from the depths of despair.

People suffering from the symptoms of depression might notice that others start to avoid them after awhile in an attempt to move away from the doom and gloom or dark mood. This can make the sufferer feel even more isolated, but it is imperative that help is gained from a medical professional so that the symptoms do not worsen over time. There may even be an underlying physical cause for the symptoms of depression, so the sooner a person acknowledges depression and seeks help, the better.

If a doctor is not able to help, they may refer that person to a specialist or for counselling. This approach does not suit everyone but it is important to keep an open mind, because results can be unexpected and exceptional with this type of treatment.

In some cases it is possible that acknowledging depression may be difficult because a person may have lived with it for an extended period of time and therefore does not know whether it is depression or not.
Once a person has acknowledged the possibility and symptoms of depression they should remember that they do not have to feel this way for the rest of their life. It is extremely important to seek and accept help from other trustworthy people who can be of assistance in providing guidance to a much happier and fulfilling way of life.

Sunday, August 25, 2013

The Basics Of Manic Depressive Illness


Current thinking with regard to manic depressive illness is pretty much like the picture you see to the left. Your life might turn out to be a roller coaster ride but the good news is that modern therapies seem to be making much progress towards smoothing out the peaks and valleys while bringing a modicum of normality to your life.

Generally speaking, it is not the type of condition that can be cured to the point of no return. The best case scenario will allow you to keep your symptoms at bay while you go about leading as perfectly as normal of a lifestyle as possible. For some people, this never happens and in fact, dealing with manic depressive illness can become unbearable. Learning to live with the condition is no small undertaking, but like everything else in life, where there is a will, there is a way!

As a human being, it is actually rather normal to swing from a state of happiness to a state of sadness and vice versa. What makes this condition unique is that when it comes to the manic depressive illness, the extreme emotions can be very strong. For instance, if you suffer from this condition, it will not be unusual for you at all to swing from one extreme emotional state to the opposite end in what would seem like no time at all. What you will have to do is learn how to control them, which for most people will require the help of medication.

The manic depressive illness symptoms will usually arrive in people's late adolescent years. Diagnosing it can be very hard, since it arrives with many other factors specific to that age group. It is very important that you get a proper diagnosis as early as possible, so that you can get proper treatment. Once you start to treat the condition, you will start to feel better. Your mood swings will not be as severe as before you began treatment. Ideally, you will be able to control your wide mood swings to the point that most people close to you will not even be able to notice anything.

A cornerstone of good treatment for patients who suffer from manic depressive illness is to be surrounded with people who are supportive. Always having someone to talk to, especially in moments when you feel really sad, is very critical to your wellbeing. That support person can prevent you from doing the kinds of things that you should not do. They will help you to see the error of your ways, such as preventing an extravagant purchase or doing some bodily harm to yourself. If you see yourself in this position, be sure to get some help today for a better tomorrow!

The Ups And Downs Of Depression


Clinical depression is known to impact the lives of one out of every six people in their lifetime. But the sad reality is that the medical community still does not entirely understand exactly what causes depression to occur in one person and not in another.

Yes, we do know that depression is hereditary.

Depression can often be found to run throughout the generations of the same family invading the DNA molecules which make up a particular family's genes. This causes the family members to be more susceptible to depression.

However, there is another school of thought that says perhaps the real reason we see depression run in families is that it is also environmental in that it all depends on how the children are raised. If they see the affects of depression encroaching on the lives of their family and they see the results then they will learn to deal with life the very same way.

Even though we are quite clear that depression runs in families, depression is also seen in those without any family history. Stress resulting from a variety of issues, trauma, or even prescription medications or illegal drugs have all been known to cause depression.

Riding the ups and downs of depression can leave you even more exhausted that the last wave of depression you faced. Depression is known to run in cycles. You may feel completely fine one day and the next day you may be completely and utterly unable to get yourself out of the bed and out of your night clothes. The dramatic ranges of emotions are well documented in cases of depression.

Many healthcare providers and scientist alike believe that many suffering with depression manifest a chemical imbalance of Norepinephrine and Serotonin which are the feel good neurotransmitters found in the central nervous system and in the brain.

These neurotransmitters work to help control feelings of happiness and well being. The neurotransmitter Norepinephrine is thought to be a stress hormone; while Serotonin is thought to control hunger, overall moods, sleep and sexual feelings.
When these chemicals get out of whack they are thought to cause depression.

So if you think about it, when these neurotransmitters are out of balance it only makes sense that the roller coaster ride of depression would result. As these levels of these chemical rises and falls thereto go the emotions and feelings associated with them.

The real question is why do some people experience peaks and valleys with their chemical make up while others seem to be more stable. Again, it begs the question is it really the environment in which you were raised or is it truly the ebb and flow of the neurotransmitters that alter feelings causing the dramatic impact of depression.

Do you mirror your family because that is all you know how to do, it is the only way you know to respond or is it that you are genetically and chemically bound to your family and because of that simply have no choice of being impacted by depression.

We need more research and time to study this issue before there is a definitive answer. What we do know is that regardless of the reason why, we do know that depression tends to run in families and if you have a family member that has dealt with the issue then you should be aware of the possibility that you too could be fighting the same battle one day.

Be aware, seek help early and learn what you can do in order to prevent depression before it takes control of your life.

How to Become Happy Again!


This is not a treatment for depression. I am not qualified to give that. It is simply a series of techniques that I researched from many areas and disciplines, put together into a program, and utilised to overcome depression in my life. The program worked for me. It may not work for you, and is offered as information only.

Depression is sometimes a temporary condition, brought about by some event in life, and can often be relieved by some of the techniques I will mention. If it is deeper or longer lasting, it may be clinical depression or some other more serious form of depression, and while benefiting from the same techniques, may need to be treated by a medical professional or psychologist.

Depression is defined by a standard set of symptoms described in the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders. They are:

poor appetite and significant weight loss, or increased appetite and significant weight gain;

insomnia, or increased sleep;

agitation, or retardation, of movement and thought;

loss of interest or pleasure in usual activities or decrease in sexual drive;

fatigue and loss of energy;

feelings of worthlessness, self-reproach, or excessive or inappropriate guilt;

diminished ability to think or concentrate, or indecisiveness;

recurrent thoughts of death or suicide, or suicide attempts.

Not many people will have all of these symptoms, but if some exist, then there could be a degree of depression which needs to be addressed. One thing that depression does is rob you of a lot of energy, and as this is an extract from a book about gaining energy, I will discuss some methods to combat depression and thereby gain more energy.

Depression gets worse when you do nothing. When you just sit and think about whatever it is that is bothering you, you will probably end up feeling more depressed and very low in energy.

Sitting in bad feelings just makes the feelings worse. The thing to realize is that feelings do not create actions. It is actions that create feelings. And good, positive actions create good, positive feelings and lift your mood. So the first step out of depression is to do something, to move forward in life taking action, no matter how small to start with. Don't wait till you feel like taking action, or until you feel more confident, because you may never feel that way UNTIL you starting DOING something.

Physiology is very important. This means the way you move, the way you stand and sit. If you are finding yourself looking down, with shoulders hunched over, and breathing very shallow breaths, and thinking "poor me" thoughts, you can make an almost immediate change by changing your physiology. Stand or sit up straight, pull your shoulders back, look up, smile and start thinking about a time you felt good, or a time when you felt most loved and cared for. You should experience a lightening of your mood very quickly. If you then start moving around, at a brisk pace, and DO something (even household chores), you can quickly move out of the darkness of the mood and feel happier within yourself. Try it, and if you want more information on this technique, get a copy of Unlimited Power by Anthony Robbins, who discusses physiology in great detail.

The next step is to look at what you are eating and drinking. Eating a lot of junk food, caffeine, sugar etc will make you feel worse due to its fat and sugar content and lowered nutritional value, so eat healthy, nutritious food, lots of fresh fruit, fish, vegetables and grains and drink lots of filtered water (2-3 litres a day). Give much more focus to these fresh foods than to processed food. This will help to stabilise your brain chemistry along with the positive self-talk, exercise and mediation, and as it is unbalanced brain chemistry that is a main causative effect of depression, addressing it through diet is critical.

Alcohol itself is a depressant and will not help your mood at all, so try to avoid it when depressed. Long term, it will aggravate your depression and lower your mood further while affecting your health and fitness in a negative way. Moderate social drinking with friends occasionally is fine. What I am talking about is daily drinking alone in an attempt to combat the depression and make the problems go away. It just doesn't work.

Vitamins and minerals will further strengthen your system and a good daily multivitamin together with a strong anti-oxidant supplement is a minimum to start with. Learn more about health supplements, read articles, talk to people and implement a supplement program in your diet. It is essential in today's world.

Exercise is essential as the body will produce hormones called endorphins when you exercise properly and the hormones will make you feel quite good. The increased fitness level will make you more able to cope with life's problems as well. As mentioned before, the better tuned your physical body is, the better your psychological state of mind becomes. It's when you are depressed that it's hardest to take action and exercise, but this is probably when it is most important.

Anti-depressant medication should be only be taken if necessary and on the advice of a medical professional, but sometimes is required before other techniques can work. As a natural alternative to perhaps try first, there is a herb call St. John's Wort (available from health food stores) that has been reported to be effective against light depression in many people and is a safe and natural substance. Wort usually needs to be taken for at least a month before seeing results.

Self Talk is one of the most critical techniques to combat depression and can be very effective in lifting mood. What you say to yourself all day long controls your reactions to whatever life offers you and indeed whether you see the world and its people as a dark place or a friendly place. (See separate section below).

Visualisation is also very effective. Take some time each day and while sitting and listening to some "feel good" music, relive some great times in your life, see yourself succeeding again in the future and really get into the good feelings. Think about what you can do to make life better, and see yourself doing it, and feel the great feelings that come with the accomplishment. And when any bad thoughts from the past come, acknowledge them and replace them with good thoughts about what you can do today and in the future to make your life what you want it to be. Do this every day as part of your routine.

Meditation is also part of the treatment and though you may not feel like meditating to start with, it will quickly become an effective part of your treatment. It also has many other health and psychological benefits as well that may amaze you after you have been practising it for a while. (See separate section below).

Breathing - Most people breathe in a shallow fashion and therefore do not get enough oxygen. Ten deep breaths taken 2-3 times a day will get more oxygen into your blood and your brain, and this will have a positive effect on mood and relaxation.

Self Talk

Of all the things in your life that influence your attitude, the one you have the most control over is your self talk. Negative self talk will give you a negative attitude which will give you poor results. Positive self talk will give you a more positive attitude which will give you great results. The key to controlling your self talk is awareness of what you are saying to yourself on a consistent basis.

To say things like, "I can't, this never works for me, I am no good at this, why do I always feel tired, I've never had energy" etc program your mind for more of the same. To program your mind positively, you need to become aware of the negative firstly, and then replace them with supporting statements. A technique that I have used successfully is based on Cognitive Therapy and is described next.

Cognitive Therapy has helped me in the past to claw my way out negative thinking and to start making positive changes. The technique I used was to carry a mini tape recorder around for three days (a notepad would be nearly as effective). I recorded every negative thought as they occurred.

After 3 days, I sat down and transcribed all the negative thoughts into a list. It made a hell of a horrible list, and when I realised what had been running round inside my head, I knew what had been causing my problems. Like many others, I had been talking to myself in a very negative and non supportive way.

I went through every statement and wrote it in reverse. i.e. "I am a loser" became "I am a winner". "I don't know what I'm doing" became "I know exactly what I'm doing". "I can't do this" became "I can easily do this" etc.... You get the idea.

I ended up with a list of 32 positive statements, which were the exact opposite of what I was saying to myself all the time. This was the important part because the statements related to MY thinking. They were not someone else's list of affirmations. I realised that I had dirty water (negative thoughts) circulating in my mind, and the only way to make it clean was to gradually replace it with pure water (the positive statements that were the EXACT opposite of the negative thoughts).

I put the list up on my bathroom mirror and started saying them aloud a couple of times morning and night. It took about three days to start to notice the difference and I continued reading them for a month. Now I am rarely have those negative thoughts, and am when I do, I am able to catch and replace them quickly and easily.

Meditation and Relaxation

Meditation is a simple, natural, mental technique that is practiced twice daily for 15-20 minutes while seated comfortably. Because it is effortless and natural, it requires no special abilities and can be practiced by anyone -- anyone who can think can meditate! More than one million people of all ages, nationalities, religions, and walks of life are already enjoying the great benefits of this technique, which include:

deep rest (deeper than the deepest point of sleep) and relaxation

increased energy and vitality

improved health

greater alertness and clarity of mind

improved memory

increased intelligence and creativity

greater happiness

improved interpersonal relationships

ability to accomplish more with less effort

less problems in life

Studies of meditation indicate that it tends to produce normalisation in all areas of life. It reduces stress, improves health, enriches mental functioning, enhances personal relationships, and increases job productivity and job satisfaction.

Listed below are some of the findings of the effects of meditation.

Improved Mental Abilities: Increased intelligence, increased creativity, improved learning ability, improved memory, improved reaction time, higher levels of moral reasoning, improved academic achievement, greater orderliness of brain functioning, increased self-actualisation.

Improved Health: Reduced stress and anxiety, reduced hospitalisation, reduced incidence of disease, reduced need for out-patient medical care, reduced health care costs, reduced use of alcohol and drugs, improved cardiovascular health, reduced physical complaints, increased longevity.

Improved Social Behaviour: Improved self-confidence, reduced anxiety, improved family life, improved relationships at home and at work, increased tolerance, improved job performance, increased job satisfaction.

Meditation Technique

Aside from generating groundbreaking research, it may be that Herbert Benson's most lasting contribution is the development and popularisation of a meditative technique with no religious overlay. This approach allows those who are not religious, or whose beliefs may appear to conflict with the teachings connected to a particular meditation system, to nonetheless participate fully in this worthwhile, health-giving activity.

According to Benson, the relaxation response technique produces the same physiological changes as does the most popular meditation technique, the method which has been most fully researched in scientific settings.

Here is a slight adaptation of Benson's directions for evoking the relaxation response and entering a meditation state.

(1) Sit quietly in a comfortable position with your back straight. (Do not lie down).

(2) Take a few deep breaths, and as you are expelling each breath, say out loud "relaxing now" and gradually close your eyes.

(3) Deeply relax all your muscles one by one, beginning at your feet, focusing on each part of the body, and progressing up to your face and the little muscles behind your eyes. Keep them relaxed.

(4) Breathe through your nose. Become aware of your breathing. As you breathe out, say the word "ONE," silently to yourself. For one example, breathe IN... OUT, "ONE"; IN... OUT, "ONE,": etc. Breathe easily and naturally.

(5) Continue for 10 to 20 minutes. You may open your eyes if necessary to check the time, or you may use a timer with a quiet alarm function. When you finish, sit quietly for several minutes, at first with your eyes closed and later with your eyes opened. Stretch your arms, then the rest of your body and take a few deep breaths again. Do not stand up for a few minutes.

(6) Do not worry about whether you are successful in achieving a deep level of relaxation. Maintain a passive attitude and permit relaxation to occur at its own pace. When distracting thoughts occur, try to ignore them by not dwelling upon them and return to repeating "ONE." With practice, the response should come with little effort. Practice the technique once or twice daily, but not within two hours after any meal, since the digestive processes seem to interfere with the elicitation of the relaxation response.

The word "ONE" may be replaced by a mantra if preferred. Some possible mantras from various traditions are:

Om So Hum Om Mani Padme Hum Om Nima Shivaya Hari Om Tat twam asi

The sounds used for these mantras, which are derived from Sanskrit, are not intended to engage the cognitive mind.

It is common for beginners at meditation (of all types) to experience a great deal of mental chatter and clutter. If this happens to you, it does not mean that you are doing anything wrong. Just notice each thought as it comes, and then let it pass on by, using the mantra to, as it were, break the spell.

Most of the information presented here on meditation is drawn from articles published on the Internet by Daniel Redwood, Herbert Benson and other highly qualified researchers.

Summary

These are a few techniques that people have found effective, so if depressed or even if you just have the blues for whatever reason, try the combination of techniques presented here for at least a month. Results with different people can and will vary, and the time to achieve results must obviously vary as well.

The important thing to remember is that these techniques will give you a greater degree of control over the way you feel. Dealing with depression is a matter of doing all the small things mentioned on a daily basis, and the results you achieve will be in direct proportion to how consistent and how disciplined you are in doing the techniques every day. You can choose to be happy anytime you want, and you don't need anyone to make you happy. All you need to do is choose, and the funny thing is that when you become happy all the time, no matter what your circumstances, nice people will just start coming into your life, because you are a happy person and happy people are attracted to other happy people. And with the happy people that come into you life, will also come the opportunities that will allow you to be successful in every area of your life.

It's all your choice...anytime you want....

Just remember the key - Actions create feelings. Feelings do not create actions. So take action, and you can start to enjoy life again.

Disclaimer

The information and advice contained in this article is based on the research and personal experiences of the author. They are intended as information only and not as a substitute for consulting with your doctor or health care professional. The author is not responsible in any way for any adverse effect or consequences resulting from any suggestions or use of any other information contained herein. All matters pertaining to your physical, mental and emotional health should be supervised by your health care professional.

A Basic Description of Bipolar Disorder Or Manic Depression


Bipolar disorder-also commonly referred to as "manic depression" or "manic-depressive disorder"-is a mental illness which is caused by a disorder of the brain. Individuals who suffer from this mental illness experience severe mood swings that can cause detrimental behaviors which are not only harmful to themselves, but agonizing to their loved ones as well.

In many cases the families of the individual who has this disorder often find it very confusing and attribute their actions to just bad behavior or poor judgment and perceive it as something which the individual can control simply by modifying their behavior or lifestyle.

Extreme Mood Swings Caused by Bipolar Disorder

Individuals who have bipolar disorder experience extreme mood swings ranging from extreme "highs" to extreme "lows". The "highs" -which are called "manic episodes"- cause them to be overly excited or euphoric and can lead to detrimental behaviors such as spending money excessively or promiscuous sexual activities.

The "lows" or "depression" experienced by those with Bipolar Disorder results in the symptoms of depression, reduced energy levels, restlessness, and could result in thoughts of suicide. These variations in mood swings are what make the diagnosis of bipolar disorder very difficult as these individuals can sometimes experience short episodes which can appear to be just a phase or another form of mental illness.

The Different Types of Bipolar Disorder

There are various types of this mental disorder of which all include the primary symptom of mood swings. When an individual experiences a "manic episode" at least one time in their life, this condition is known is called "bipolar I". In individuals who experience both the manic and depression episodes in variations overtime, this type is known as "bipolar II", however, in bipolar II the individual never reaches a full state of "mania".

Another type of these disorder is referred to as "rapid cycling" where the individual is experiencing episodes of both mania and depression three to four times per year. Mixed bipolar disorder is when an individual experiences these mood swings simultaneously or one right after the other. Cyclothymia is a milder form of bipolar in which the individual experiences the symptoms of bipolar disorder but to a lesser degree.

Affirmations That Can Help You Manifest the Law of Success


The law of success has enabled millions of people to live inspiring and fulfilling lives. There is no doubt that a lifestyle built on the premise of positivity yields great rewards for those who choose to live this way. But there is no such thing as an overnight success. The results a person receives from applying the principles of attraction may vary. Some results manifest sooner than others. A lot of people give up on the idea after a few days of trying.

One of the most efficient tools that can help you manifest positivity in your life is the use of positive affirmations. The prerequisite of success is belief. You have to believe before you achieve. If you're belief is not at 100%, these affirmations may help you get there:

1. "I am healthy and happy."
Health and happiness are among the most important goals one can hope for. In fact, many practitioners of the law of success prioritize these goals over financial and career goals. Maintain your personal health and happiness by using positive affirmations. Telling yourself that you're healthy and happy encourages you to live a healthy lifestyle and prevents you from consuming vices that are commonly associated with depression like drugs and alcohol.

2. "I am getting wealthier each day."
Hard work and determination are the primary prerequisites of wealth. However, it's very hard to remain focused when you don't get immediate results from your hard work and labor. You may lose your morale and decide to give up when the going gets tough. Positive affirmations that remind you of your progress are important to maintain your focus. Always remember that you need to maintain a positive attitude to manifest the law of success.

3. "My mind is calm."
Insecurity, fear of failure and performance anxiety are mental obstacles that may be preventing the law of success from properly manifesting in your life. Regardless of your talent and ability, it's hard to perform at a high level when you're constantly plagued with self-doubt. Positive affirmations can help you stay calm even in the most trying situations. When you're beginning to lose your composure, just tell yourself, "My mind is calm."

4. "My emotions are under my control."
There are many situations in life that requires us to control our temper. Anger rarely resolves a situation. For the most part, expressions of anger have a tendency to escalate situations and make them worse. The law of success is all about positive emotions, thoughts and actions. Feelings such as anger, jealousy and envy tend to make us dwell in negativity. Prevent such feelings with positive affirmations that can help you keep your emotions under control.

5. "I radiate love and happiness."
No one wants to be lonely. Unfortunately, not everyone lives a lifestyle that allows for a lot of social interaction. There are times when you have to do things that you enjoy by yourself. Some people just choose not to go to the movies or have dinner out instead of doing these activities alone. Don't fall into this trap. With the help of a few positive affirmations, you can go out by yourself and have a great time! The law of success can only manifest if you allow it to. The more happiness and love you radiate, the more people would be interested in meeting you. Who knows who you might meet at a restaurant when you go there? Chances are you might find yourself an instant date!

The law of success is founded on personal belief. But belief is not an easy thing to achieve. People have different means to establish this belief. Some test themselves by constantly taking on new challenges, while others obsessively prepare before the challenge even comes. Positive affirmations are a big part of this process. Confidence and belief have to be built through time. You can't go from never competing in a marathon before to believing that you can finish a 10 kilometer race. You have to build towards that reality by training every day, pushing yourself with new challenges and telling yourself that you can do it.

Future of Depression Treatment - What Lies Ahead?


Today I'm looking into the future of depression, and so far it doesn't look that good.

Depression will become a second major cause of all deaths after a heart disease by 2020, according to the World Health Organization (WHO) prognosis. These days depression affects all ages -toddlers, teenagers, young generation, middle-aged people and our elders.

The symptoms of depression, I truly believe, weaken the whole body, and it becomes a vicious circle: the more you're depressed the more you're ill, the more you're ill - the more you're depressed. In fact, there is some research looking into the connection between the inflammatory disorders (for example, rheumatoid arthritis, hay fever, atherosclerosis) and depression, especially bipolar disorder. The thought is to try and see if immunotherapy will help in both cases.

So, what lies ahead for the future of depression treatment?

- The scientists are researching the gene behind the depression. The idea is simple - to try new medications first and adjust the dose on this gene, instead of going through months of different antidepressants in hope that one of them will work for the patient.

- ECT (Electroconvulsive Therapy or shock therapy), which is given to the patients with severe depression. What happens is that you are anesthetised, then electric currents released for 40 seconds into your brain, which causes mini seizures, which in turn help releasing a lot of neurotransmitters into your brain (among those serotonin, dopamine and noradrenaline that improve our mood). Of course, there are side effects as well, and one of those like with all seizures is a short memory loss. The researchers now experiment with narrowing the electric waveform to improve the results.

- TMS (Transcranial Magnetic Stimulation) works a bit like ECT stimulating the release of neurotransmitters into the brain with the help of magnetic impulses similar to those in MRI scan. It still mostly in experimental stage, and I heard that the treatment costs about $ 6,000(!) requiring daily sessions for 4-6 weeks. There are mostly no side effects apart from sense of discomfort and occasional headache. Let's hope with more research the treatment will become more affordable.

- Obviously, the antidepressant drugs are here for a long run as well. There will be more new pills, hopefully with less side effects.

This is all I could find. If anyone knows of more research into the future of depression treatment, please, share.